New PDF release: Advanced Topics in Forensic DNA Typing: Interpretation

By John M. Butler Ph.D. (Analytical Chemistry) University of Virginia

ISBN-10: 0124052134

ISBN-13: 9780124052130

The first variation of Forensic DNA Typing, published in 2001, via John Butler fast proven itself because the gold-standard reference for the sphere. Over the subsequent ten years, the great volume of latest info exposed has ended in this new quantity, Advanced subject matters in Forensic DNA Typing: Interpretation. This ebook builds upon the former variants of Forensic DNA Typing books, yet with a spotlight on mix interpretation and statistical research and is a significant other to the bestselling Advanced issues in Forensic DNA Typing: Methodology, released in September 2011.

  • Provides forensic DNA analysts assurance of the the most important subject of DNA blend interpretation and statistical research of DNA evidence
  • Worked mix examples illustrate the influence of alternative statistical methods for reporting results
  • Includes allele frequencies for twenty-four time-honored autosomal STR loci, the revised caliber coverage criteria which went into influence September 2011

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Extra resources for Advanced Topics in Forensic DNA Typing: Interpretation

Example text

S. population groups. , et al. (2013). S. population data for 29 autosomal STR loci. Forensic Science International: Genetics, 7, e82ee83. 6 Layout of loci by dye channel and relative size in selected Life Technologies (Applied Biosystems, ABI) STR kits. 20 1. 7 Layout of loci by dye channel and relative size in selected Promega PowerPlex STR kits (Promega 2012). regardless of how many other loci match. This binary (match/no-match) approach becomes problematic with low-level evidentiary DNA samples where stocastic allele dropout is likely.

Analytical Biochemistry, 128, 227e231. Mayrand, P. , et al. (1992). The use of fluorescence detection and internal lane standards to size PCR products automatically. Applied and Theoretical Electrophoresis, 3(1), 1e11. Rosenblum, B. , et al. (1997). Improved single-strand DNA sizing accuracy in capillary electrophoresis. Nucleic Acids Research, 25, 3925e3929. Ziegle, J. , et al. (1992). Application of automated DNA sizing technology for genotyping microsatellite loci. Genomics, 14(4), 1026e1031.

8e11. pdf. 16 1. ” With the availability of these interpretation guidelines, laboratories were “encouraged to review their standard operating procedures and validation data and to update their procedures as needed” (SWGDAM 2010). As will be emphasized throughout this book, a forensic DNA laboratory should develop STR interpretation guidelines based upon its own validation studies. Information from STR kit and instrument manufacturers and results reported in the literature can be helpful. Practical experience with instrumentation and results from performing casework are also important factors in developing an interpretation strategy.

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Advanced Topics in Forensic DNA Typing: Interpretation by John M. Butler Ph.D. (Analytical Chemistry) University of Virginia

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